Synthesis of 3-Bromo-4-phenylisothiazole-5-carboxylic Acid and 3-Bromoisothiazole-5-carboxylic Acid
نویسندگان
چکیده
Reactions of 3-bromo-4-phenylisothiazole-5-carboxamide and 3-bromoisothiazole-5-carboxamide with NaNO2 (4 equiv.), in TFA, at ca. 0 °C gave the carboxylic acid products 99% 95% yields, respectively. The two compounds were fully characterized.
منابع مشابه
5-Benzoylamino-3-bromo-4-(4-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid.
The title compound, C18H15BrN2O5, a promising N-protected alpha-amino acid, was synthesized directly from an unusual bromo dipole and a 4-(arylmethylene)oxazolone. The crystal packing of the title compound is a racemic mixture. Peculiar graph-set motifs driven by the most important hydrogen bonds are described.
متن کامل5-Methylisoxazole-4-carboxylic acid
In the title compound, C(5)H(5)NO(3), the mol-ecule lies on a crystallographic mirror plane with one half-mol-ecule in the asymmetric unit. An intramolecular C-H⋯O inter-action is present. In the crystal, strong inter-molecular O-H⋯N hydrogen bonds result in the formation of a linear chain structure along [100], and there are also weak C-H⋯O hydrogen bonds between the chains which help to stabi...
متن کاملSYNTHESIS OF 3-ARYLMETHYL-4- THIAZOLIDINE-CARBOXYLIC ACID-2-ONES AND 2-THIONES
Barium salts of dibenzylidene cystines 8a-c were obtained from the reaction of Lcystine with benzaldehyde or its derivatives in the presence of barium hydroxide. Their reduction with zinc and hydrochloric acid in methanol yielded the Narylmethylcysteines ?9a-c?. These can, in turn, be converted by esterification into the methyl esters ?10 a-c. ?Reaction of N, N'-carbonyl diimidazole (Im C...
متن کامل1-Cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid
The asymmetric unit of the title compound, C(18)H(18)N(2)O(3), contains two mol-ecules. The fused rings of both mol-ecules are almost planar, with dihedral angles of 3.1 (1) and 2.8 (2)° between the fused rings. The furan rings are rotated by 43.85 (15) and -21.07 (9)° with respect to the planes of the attached bnzimidazole systems. In the crystal, mol-ecules are linked into infinite chains by ...
متن کاملAttempts of activating carboxylic group of 3‐amine‐1H‐pyrazole‐5‐carboxylic acid using azide method
Despite the fact that this system is weakly represented in nature [1÷5], the pyrazole is well-known pharmacophore [6] and plays important role for broad-spectrum drugs. The derivatives containing pyrazole structure belong to group of antibiotics used against viral families containing RNA or DNA genome, such as e.g. HIV. Moreover, they are used as analgesic and anti-inflammatory drugs [1] and al...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molbank
سال: 2023
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1557